A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer
Runjie Song, Peilan Guo, Xin Ren, Lijun Zhou, Peng Li, Nafis A Rahman, S?awomir Wo?czyński, Xiru Li, Yanjun Zhang, Mei Liu, Jiali Liu & Xiangdong Li
PMID：37408008
Epub：2023 Jul 5
Engineered hypermutation adapts cyanobacterial photosynthesis to combined high light and high temperature stress
Huili Sun, Guodong Luan, Yifan Ma, Wenjing Lou, Rongze Chen, Dandan Feng, Shanshan Zhang, Jiahui Sun & Xuefeng Lu
PMID：36871084
Epub：2023 Mar 4
YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells
Peiqi Wang, Lingyi Huang, Fan Yang, Wanxi Chen, Ding Bai, Yongwen Guo
PMID：37197086
Epub：2023 May 14
A novel salivary effector, BtE3, is essential for whitefly performance on host plants
Zhengke Peng, Qi Su, Jun Ren, Lixia Tian, Yang Zeng, Yuting Yang, Shaoli Wang, Wen Xie, Qingjun Wu, Zhenyu Li, Youjun Zhang
PMID：36648335
Epub：2023 Mar 28
Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity
Yajun Zhou, Xing Lu, Xiaoqing Wang, Tianlei Ying, Xiangshi Tan
PMID：36835479
Epub：2023 Feb 17
Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest
Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Li-Sha Zheng, Wei Dou, Yu Peng, Wen-Jie Bai, Zhen-Yu Li, John Vontas & Jin-Jun Wang
PMID：37667263
Epub：2023 Sep 5
Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication
Xifeng Hu, Zheng Chen, Xiangdong Wu, Zhen Ding, Yu Huang, Qiuling Fu, Zhen Chen, Huansheng Wu
PMID：36602364
Epub：2023 Jan 31
Flexible Amperometric Immunosensor Based on Colloidal Quantum Dots for Detecting the Myeloperoxidase (MPO) Systemic Inflammation Biomarker
Yanbing Tao,Yunong Zhao,Le Wang,Jing Huang,Yan Chen,Qing Huang,Boxiang Song,Hua-Yao Li,Jianjun Chen,Huan Liu
PMID：36832021
Epub：2023 Feb 10
Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies
Mingtao Liu,Hui Gan, Zhiman Liang, Li Liu, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng, Baoqing Sun
PMID：37007494
Epub：2023 Mar 16
The Additional 15 nt of 5′ UTR in a Novel Recombinant Isolate of Chilli Veinal Mottle Virus in Solanum nigrum L. Is Crucial for Infection
Q. Wan, Kaiyue Zheng, Jian Wu, Shan Bu, Mengting Jiao, Huijie Zhou, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Hairu Chen, Fei Yan, Jiejun Peng
PMID：37515116
Epub：2023 Jun 23
Downregulation of lncRNA NEAT1 interacts with miR-374b-5p/PGAP1 axis to aggravate the development of osteoarthritis
Feiri Huang, Zhongliang Su, Jie Yang, Xizhen Zhao & Yaozeng Xu
PMID：37691099
Epub：2023 Sep 11
CD163+ and CD14+ macrophages are increased in obese children
Nikita S. Denisov, Lyudmila V. Spirina, Iuliia G. Samoilova, Ekaterina M. Kamenskih, Ksenya A. Chubakova, Daria A. Sitnikova,Dmitry A. Svarovsky
PMID：37563845
Epub：2023 Aug 11
Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies
Zixian Lu, Mei Yi, Taoli Chen, Yue He, Xia Fan, Hui Chen, Yinli Huang, Jianlou Niu, Xiaoqing Yan
PMID：37458432
Epub：2023 Jun 30
DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
Yejinpeng Wang, Lingao Ju, Gang Wang, Kaiyu Qian, Wan Jin, Mingxing Li, Jingtian Yu, Yiliang Shi, Yongzhi Wang, Yi Zhang, Yu Xiao & Xinghuan Wang
PMID：37105989
Epub：2023 Apr 27
Identification of an immunogenic epitope and protective antibody against the furin cleavage site of SARS-CoV-2
Lili Li, Meiling Gao, Jie Li, Xuping Xie, Hui Zhao, Yanan Wang, Xin Xu, Shulong Zu , Chunfeng Chen, Dingyi Wan, Jing Duan, Jingfeng Wang, Saba R. Aliyari, Sarah Gold, Jicai Zhang, Cheng-Feng Qin, Pei-Yong Shi, Heng Yang, Genhong Cheng
PMID：36508877
Epub：2023 Jan
Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis
Ni Lian, Yujie Chen, Sihan Chen, Ying Zhang, Hao Chen, Yong Yang, Heng Gu, Qing Chen, Min Li & Xu Chen
PMID：37673869
Epub：2023 Sep 7
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer
Kanghua Xiao, Shengmeng Peng, Junlin Lu, Ting Zhou, Xuwei Hong, Siting Chen, Guangyao Liu, Hong Li, Jian Huang, Xu Chen, Tianxin Lin
PMID：37422473
Epub：2023 Jul 8
Evaluation of the Immunological Efficacy of an LNP-mRNA Vaccine Prepared from Varicella Zoster Virus Glycoprotein gE with a Double-Mutated Carboxyl Terminus in Different Untranslated Regions in Mice
Yunfei Wang, Han Cao, Kangyang Lin, Jingping Hu, Ning Luan, Cunbao Liu
PMID：37766151
Epub：2023 Sep 11
Development of an Antigen Detection Kit Capable of Discriminating the Omicron Mutants of SARS-CoV-2
Jiaji Li,Jinrong Shi,Zhijun Zhou,Bo Yang,Jiamin Cao,Zhongsen Cao,Qiang Zeng,Zheng Hu,Xiaoming Yang
PMID：36851181
Epub：2023 Jan 30
Study of the Effects of Several SARS-CoV-2 Structural Proteins on Antiviral Immunity
Rong Yue, Fengyuan Zeng, Danjing Ma, Ziyan Meng, Xinghang Li, Zhenxiao Zhang, Haobo Zhang, Qi Li, Langxi Xu, Zhenye Niu, Dandan Li, Yun Liao, Guorun Jiang, Li Yu, Heng Zhao, Ying Zhang, Longding Liu, Qihan Li
PMID：36992107
Epub：2023 Feb 23
A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice
Shimeng Bai, Tianhan Yang, Cuisong Zhu, Meiqi Feng, LiZhang, Ziling Zhang, Xiang Wang, Rui Yu, Xinghao Pan, Chen Zhao, Jianqing Xu, Xiaoyan Zhang
PMID：36761167
Epub：2023 Jan 17
Pilot Study Results on Antibodies to the S- and N-Proteins of SARS-CoV-2 in Paired Sera from COVID-19 Patients with Varying Severity
Yulia Desheva, Anna Lerner, Tamara Shvedova, Olga Kopteva, Polina Kudar, Irina Koroleva, Galina Leontieva, Alexander Suvorov
PMID：36975366
Epub：2023 Feb 27
Comparison of Immune Responses between Inactivated and mRNA SARS-CoV-2 Vaccines Used for a Booster Dose in Mice
Luan N, Cao H, Wang Y, Lin K, Hu J, Liu C
PMID：37376650
Epub：2023 Jun 11
Insulin-like growth factor 1 promotes the gonadal development of Pampus argenteus by regulating energy metabolism
Yaya Li, Chang Li, Yangfei Fu, Ruixian Wang, Yang Yang, Man Zhang, Youyi Zhang, Xiangbing Wang, Guanlin Wang, Huan Jiang, Yushan Zou, Jiabao Hu, Chunyang Guo, Yajun Wang
PMID：37228017
Epub：2023 Aug 10
Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin
A. V. Sokolov, I. N. Isakova-Sivak, D. A. Mezhenskaya, V. A. Kostevich, N. P. Gorbunov, A. Yu. Elizarova, V. A. Matyushenko, Yu. M. Berson, N. A. Grudinina, N. N. Kolmakov, Y. A. Zabrodskaya, A. S. Komlev, I. V. Semak, A. I. Budevich, L. G. Rudenko & V. B. Vasilyev
PMID：36334191
Epub：2023 Jun
Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain
Qingqing Feng, Keman Cheng, Lizhuo Zhang, Xiaoyu Gao, Jie Liang, Guangna Liu, Nana Ma, Chen Xu, Ming Tang, Liting Chen, Xinwei Wang, Xuehui Ma, Jiajia Zou, Quanwei Shi, Pei Du, Qihui Wang, Guangjun Nie, Xiao Zhao
Epub：August 24, 2023
FUS regulates the alternative splicing of cell proliferation genes related to atherosclerosis
Jianjun Hou, Shaobing Yang, Ying Guo, Ning Yan, Shaobin Jia
PMID：37688506
Epub：2023 Sep 9
Comparison of the Immune Effects of an mRNA Vaccine and a Subunit Vaccine against Herpes Zoster Administered by Different Injection Methods
Kangyang Lin, Han Cao, Ning Luan, Yunfei Wang, Jingping Hu, Cunbao Liu
PMID：37243107
Epub：2023 May 20
SARS-CoV-2 RBD Conjugated to Polyglucin, Spermidine, and dsRNA Elicits a Strong Immune Response in Mice
Ekaterina A Volosnikova, Iuliia A Merkuleva, Tatiana I Esina, Dmitry N Shcherbakov, Mariya B Borgoyakova, Anastasiya A Isaeva, Valentina S Nesmeyanova, Natalia V Volkova, Svetlana V Belenkaya, Anna V Zaykovskaya, Oleg V Pyankov, Ekaterina V Starostina, Alexey M Zadorozhny, Boris N Zaitsev, Larisa I Karpenko, Alexander A Ilyichev, Elena D Danilenko
PMID：37112720
Epub：2023 Apr 6
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
Yuxia Zhou, Lu Liu, Bangming Jin, Yixuan Wu, Lifen Xu, Xuebing Chang, Laying Hu, Guifang Wang, Yali Huang, Lingyu Song, Tian Zhang, Yuanyuan Wang, Ying Xiao, Fan Zhang, Mingjun Shi, Lingling Liu, Tuanlao Wang, Rui Yan, Bing Guo
PMID：36812572
Epub：2023 May 1
Nasal immunization with AMH-INH-RFRP DNA vaccine for improving follicle development and fertility in buffaloes
Chao Chen, Xuhong Zhao, Zhigao An, Muhammad Jamil Ahmad, Kaifeng Niu, Xinxin Zhang, Pei Nie, Jiaomei Tang, Aixin Liang, Liguo Yang
PMID：36891049
Epub：2023 Feb 20
Celastrol attenuates streptozotocin-induced diabetic cardiomyopathy in mice by inhibiting the ACE / Ang II / AGTR1 signaling pathway
Xuyong Zhao, Bingwu Huang, Jianhua Zhang, Wenjun Xiang, Ning Zhu
PMID：37700366
Epub：2023 Sep 12
Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress
Yingchao Wu, Dajin Pi, Shuyao Zhou, Wuhong Wang, Huan Ye, Zhongjia Yi, Yiliu Chen, Mingzi Ouyang
PMID：37132527
Epub：2023 Jan-Dec
Generation of a blockage monoclonal antibody of LILRB1 against HLA-G
Yunlong Shen, Ruirui Zhang, Xiaohua Jiang, Jinliang Yang
PMID：37683901
Epub：2023 Sep 6
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獎勵（二選一） |
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普健生物（AtaGenix）于2012年在武漢成立，作為武漢國家生物產(chǎn)業(yè)基地公共服務平臺——光谷抗體發(fā)現(xiàn)與篩選公共服務平臺，普健生物（AtaGenix）專注于重組蛋白、抗體、診斷原料、抗體藥物發(fā)現(xiàn)等自主技術平臺的建設和下游生物醫(yī)藥產(chǎn)品的戰(zhàn)略合作。經(jīng)過10年的發(fā)展，普健生物已成為一家立足武漢，業(yè)務覆蓋全國、輻射全球的高新技術服務企業(yè)。目前公司擁有4700平米自建實驗室（包含800平高標準BSL-2級細胞房），擁有齊全蛋白抗體開發(fā)設備500余套，包括高通量蛋白純化儀、Agilent 流式細胞分析儀，全自動HPLC分析儀，openSPR蛋白、抗體親和力測定儀，Olympus熒光顯微鏡， BTX電融合儀，2*7L微生物發(fā)酵罐，中試型高壓均質(zhì)機，全自動管式化學發(fā)光儀，以及配套的高速離心機，細胞計數(shù)儀及大容量細胞培養(yǎng)搖床。公司先后獲得榮譽：3551人才計劃、高新技術企業(yè)、技術先進型服務企業(yè)、光谷瞪羚企業(yè)。
