標題：Anti-Human RAGE Antibody (XT-M4) 抗體 (RHH01901)，AntibodySystem Laboratories
名稱：抗體 Anti-Human RAGE Antibody (XT-M4) 抗體
別名: RAGE 抗體;XT-M4 抗體；RAGE;XT-M4；抗體
鏈接：https://antibodysystem.com/product/9634.htm
產(chǎn)品購買聯(lián)系方式：027-65279366 /18162686757
郵箱：biolab-reagents@atagenix.com
QQ：2663991332
貨號：RHH01901
宿主:Human
寄主物種：Human
形式：Liquid
純度：>95% by SDS-PAGE.
克隆性：Monoclonal
同種型：IgG1
靶點：RAGE/AGER
應用：ELISA,Neut
儲存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
參考文獻：
Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/- mice
Yulia Vugmeyster 1, David DeFranco, Debra D Pittman, Xin Xu
Affiliations expand
PMID: 20978371 PMCID: PMC2958578 DOI: 10.4161/mabs.2.5.13089
Free PMC article
Abstract
A neutralizing antibody to the receptor for the advanced glycation end products (anti-RAGE Ab) was developed as a potential treatment of acute and chronic inflammatory conditions. Previous pharmacology studies demonstrated efficacy of the anti-RAGE antibody in the mouse model of sepsis. We examined pharmacokinetics and lung distribution of [125I]anti-RAGE Ab in RAGE-/- and wild-type (129S5) mice following single IV administration. Serum pharmacokinetics of [125I]anti-RAGE Ab was similar in RAGE-/- and 129S5 mice, with the total body clearance of 0.3 mL/hr/kg and the elimination half-life of 11-12 days, suggesting the target expression had limited impact on overall elimination of [125I]anti-RAGE Ab from mice. [125I]Anti-RAGE Ab accumulated in the lung of 129S5 mice, with ~4% of total dose retained in the lung at days 6-27 and the lung AUC0-∞ of ~300% of that in serum. The SDS-PAGE analysis suggested that most of retained lung radioactivity was attributed to intact antibody. No accumulation of radioactivity was observed in the lung of RAGE-/- mice, indicating that lung uptake of [125I]anti-RAGE Ab was target-dependent in wild-type mice. These data suggest that the anti-RAGE Ab was able to localize to the site of RAGE expression, the lung, and support the findings in the previous pharmacology studies.
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