武漢佰樂博代理：Recombinant Mouse 4-1BB Ligand/TNFSF9 protein ,N- His Tag
產(chǎn)品鏈接：http://www.atagenix.com/product_detail-4881.html
產(chǎn)品購買聯(lián)系方式：027-65279366
純度：>90% as determined by SDS-PAGE
內(nèi)毒素：Please contact with the lab for this information.
蛋白構建：A DNA sequence encoding the mouse TNFSF9(Arg104-Glu309) was fused with the N-terminal His Tag
表達宿主：Mammalian cells
種屬：Mus musculus (Mouse)
預測分子量：22.77kDa
制劑：Supplied as solution form in PBS or lyophilized from PBS .
運輸方式：In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
穩(wěn)定性&儲存：Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
復溶：Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
分子別名：Cd137l, Cd157l, Ly63l
Note：For research use only .
參考文獻：
Mechanisms of CD40-dependent cDC1 licensing beyond costimulation. PMID: 36271147
TNFSF9 expression in primary biliary cirrhosis and its clinical significance. PMID: 20303781
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. PMID: 34290245
Editing of Genomic TNFSF9 by CRISPR-Cas9 Can Be Followed by Re-Editing of Its Transcript. PMID: 30352492
Autoinducer-2 of Fusobacterium nucleatum promotes macrophage M1 polarization via TNFSF9/IL-1β signaling. PMID: 31272064
A Novel L-Phenylalanine Dipeptide Inhibits the Growth and Metastasis of Prostate Cancer Cells via Targeting DUSP1 and TNFSF9. PMID: 36142828
4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells. PMID: 35130345
CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation. PMID: 31201235
Transcriptome Reveals Granulosa Cells Coping through Redox, Inflammatory and Metabolic Mechanisms under Acute Heat Stress. PMID: 35563749
Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas. PMID: 22213068
A novel L-phenylalanine dipeptide inhibits prostate cancer cell proliferation by targeting TNFSF9. PMID: 36804121
Autoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages. PMID: 31646072
CD137L-DCs, Potent Immune-Stimulators-History, Characteristics, and Perspectives. PMID: 31632390
Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer. PMID: 36352147
Immunization Combined with Ferroptosis Related Genes to Construct a New Prognostic Model for Head and Neck Squamous Cell Carcinoma. PMID: 36077637
Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody. PMID: 27756788
The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity. PMID: 33362756
4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity. PMID: 26106583
4-1BB: still in the midst of darkness. PMID: 10850651
4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer. PMID: 34207500
4-1 BB ligand--just another costimulating molecule? PMID: 12467303
Role of 4-1BB in immune responses. PMID: 9826581
Immune induction identified by TMT proteomics analysis in Fusobacterium nucleatum autoinducer-2 treated macrophages. PMID: 32125181
Role of 4-1BB:4-1BB ligand in cancer immunotherapy. PMID: 14671675
Construction of an immune-related gene signature for the prognosis and diagnosis of glioblastoma multiforme. PMID: 35982954
[Regulatory T cells]. PMID: 15861650
Reverse signaling through the co-stimulatory ligand, CD137L, as a critical mediator of sterile inflammation. PMID: 22526397
HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism. PMID: 25710169
Identification of CD137- and CD137L-Expressing Cells in EL-4 Tumor. PMID: 33185879
O-Glycosylating Enzyme GALNT2 Predicts Worse Prognosis in Cervical Cancer. PMID: 36110252
Modulation of TNF receptor family members to inhibit autoimmune disease. PMID: 15853742
Cytotoxic Lymphocyte-Related Gene Signature in Triple-Negative Breast Cancer. PMID: 36983639
Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. PMID: 19759901
An engineered 4-1BBL fusion protein with "activity on demand". PMID: 33239441
Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic. PMID: 33976146
Chromatin state dynamics during NK cell activation. PMID: 28402957
CD137 Regulates Bone Loss via the p53 Wnt/β-Catenin Signaling Pathways in Aged Mice. PMID: 35846320
4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. PMID: 11466348
Immunotherapy of cancer with 4-1BB. PMID: 22532596
4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. PMID: 11994439
Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. PMID: 11867564
Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB. PMID: 35812455
Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease. PMID: 19124736
Blockade of 4-1BB/4-1BB ligand interactions prevents acute rejection in rat liver transplantation. PMID: 20137373
Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. PMID: 19426223
Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. PMID: 30410017
4-1BB: still in the midst of darkness. PMID: 10850651
A functional recombinant human 4-1BB ligand for immune costimulatory therapy of cancer. PMID: 21304403
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. PMID: 34290245
Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. PMID: 29720398
Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. PMID: 15349720
The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma. PMID: 15973445
Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. PMID: 7532686
4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines. PMID: 20406989
Extracellular vesicles produced by immunomodulatory cells harboring OX40 ligand and 4-1BB ligand enhance antitumor immunity. PMID: 32939048
Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells. PMID: 10946324
Costimulation of CD28- T lymphocytes by 4-1BB ligand. PMID: 8992967
Blockade of 4-1BB and 4-1BBL interaction reduces obesity-induced skeletal muscle inflammation. PMID: 24453430
Role of 4-1BB in immune responses. PMID: 9826581
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment. PMID: 31770109
4-1 BB ligand--just another costimulating molecule? PMID: 12467303
Combination of CD19 and CD22 CAR-T cell therapy in relapsed B-cell acute lymphoblastic leukemia after allogeneic transplantation. PMID: 33725422
Lipopolysaccharide preferentially induces 4-1BB ligand expression on human monocyte-derived dendritic cells. PMID: 14687728
4-1BB/4-1BBL interaction promotes obesity-induced adipose inflammation by triggering bidirectional inflammatory signaling in adipocytes/macrophages. PMID: 23316108
Costimulatory molecules as vaccine adjuvants: to 4-1BB or not to 4-1BB? PMID: 25195512
Expansion of NK Cells Using Genetically Engineered K562 Feeder Cells. PMID: 27177665
Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. PMID: 11564827
Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration. PMID: 19745604
Dispensable role for 4-1BB and 4-1BBL in development of vaccinia virus-specific CD8 T cells. PMID: 22037570
Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. PMID: 8405064
4-1BB enhancement of CAR T function requires NF-κB and TRAFs. PMID: 30232281
4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells. PMID: 35130345
Crystallization and preliminary X-ray crystallographic study of the extracellular domain of the 4-1BB ligand, a member of the TNF family. PMID: 16511253
The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. PMID: 20032458
Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. PMID: 17977894
Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15. PMID: 34244816
