標題：依決洛單抗 ，Edrecolomab，CAS:156586-89-9， AntibodySystem Laboratories

貨號：DHD17403

產(chǎn)品鏈接：http://www.atagenix.com/product_detail-75223.html

別名：17-1A, CAS: 156586-89-9

簡介：

Edrecolomab (Panorex) 是一種針對細胞表面糖蛋白 17-1A 的小鼠單克隆抗體，在上皮組織和腫瘤上表達。Edrecolomab 顯示出抗腫瘤活性，可用于結(jié)直腸癌的研究。

貨號：DHD17403

產(chǎn)品品牌：Antibodysystem

通用名：Edrecolomab

純度：>95% by SDS-PAGE.

濃度：1mg/ml

Formulationicon：0.01M PBS, pH 7.4.

內(nèi)毒素：Please contact with the lab for this information.

別名：17-1A

靶點;物種：Human CD326/EPCAM

種類：Mus musculus

受體鑒定：IgG2a-kappa

CAS: 156586-89-9

存儲條件：

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Store at +4°C short term (1-2 weeks).

Store at -20 °C 12 months.

Store at -80°C long term.

參考文獻：

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Antibody Based EpCAM Targeted Therapy of Cancer, Review and Update. PMID: 29295696
Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. PMID: 12241873
Technology evaluation: edrecolomab, Centocor Inc. PMID: 11249762
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Edrecolomab in the adjuvant treatment of colorectal carcinoma. PMID: 12517501
Edrecolomab (Panorex) as adjuvant therapy for stage II colon cancer. PMID: 12445374
Lessons learned from the edrecolomab story: how a checkered past became a checkered flag for monoclonal antibodies in colorectal cancer therapy. PMID: 15933417
When wishful thinking leads to a misty-eyed appraisal: the story of the adjuvant colon cancer trials with edrecolomab. PMID: 19273695
A pilot study of edrecolomab (Panorex, 17-1A antibody) and capecitabine in patients with advanced or metastatic adenocarcinoma. PMID: 12743982
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A clinical trial of edrecolomab, interleukin-2 and GM-CSF in patients with advanced colorectal cancer. PMID: 11182031
Adjuvant therapy with the monoclonal antibody Edrecolomab plus fluorouracil-based therapy does not improve overall survival of patients with stage III colon cancer. PMID: 19273708
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Radiation and image distortion in the panorex x-ray unit. PMID: 14033188
Biologic determinants of tumor recurrence in stage II colon cancer: validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581. PMID: 23530100
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Influence of immunomodulatory drugs on the cytotoxicity induced by monoclonal antibody 17-1A and interleukin-2. PMID: 17562330
Yeast cell surface display system for determination of humoral response to active immunization with a monoclonal antibody against EpCAM. PMID: 18321588
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Expression of the 17-1A antigen in gastric and gastro-oesophageal junction adenocarcinomas: a potential immunotherapeutic target? PMID: 10655996
Expression of epithelial-cell adhesion molecule (Ep-CAM) in small cell lung cancer as defined by monoclonal antibodies 17-1A and BerEP4. PMID: 16227163
Immune changes in patients with colorectal cancer treated by adjuvant therapy with monoclonal antibody 17-1A: a pilot study. PMID: 12962368
Prestimulation of monocytes by the cytokines GM-CSF or IL-2 enhances the antibody dependent cellular cytotoxicity of monoclonal antibody 17-1A. PMID: 11031784
Clinical effects of monoclonal antibody 17-1A combined with granulocyte/macrophage-colony-stimulating factor and interleukin-2 for treatment of patients with advanced colorectal carcinoma. PMID: 10550551
Anti-EpCAM monoclonal antibody (MAb17-1A) based treatment combined with alpha-interferon, 5-fluorouracil and granulocyte-macrophage colony-stimulating factor in patients with metastatic colorectal carcinoma. PMID: 15289873
Treatment of gastrointestinal tumors with MAb17-1A. PMID: 16312837
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Alteration of interleukin 2 (IL-2) pharmacokinetics and function by IL-2 antibodies induced after treatment of colorectal carcinoma patients with a combination of monoclonal antibody 17-1A, granulocyte macrophage colony-stimulating factor, and IL-2. PMID: 11350880
Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer. PMID: 11076666
Augmentation of 17-1A-induced antibody-dependent cellular cytotoxicity by the triple cytokine combination of interferon-alpha, interleukin-2, and interleukin-12. PMID: 10916758
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